I never did for fear of lag...but i imagine it would have been a blast!
My preferred minions were the Gangers....especially for the Gang Warfare power. The minions show up shooting everything in sight, and they always took the boss agro off me and the boys so we could take him down without trouble.
I never took much in the way of support, I specialized in shooting along with the boys...more powers to max out for damage and accuracy.
The sheer fire power of such a group has got to be devastating.