I know there have been discussions about targeting options in CoT in the past.
It just struck me after actually getting back into CoX that they already had some level of action/smart targeting. If you mash a power without an enemy selected, it'll target the one you're looking at.
I'm not sure how it picks, if it selects the target nearest the cursor or nearest to the player or what. But it is there.
I admit this might just be news to me but I didn't remember it working this way.